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Karen Brassinga Sep 2022.jpg


Ph.D. Microbiology and Immunology (2002)
McGill University

B.Sc. (Agr.) Microbiology (1995)
Macdonald Campus, McGill University


Post-Doctoral Research Training (2004-2008)
Div.of Infectious Diseases and Int'l Health
Department of Internal Medicine
University of Virginia School of Medicine


Infectious Disease Research Centre (2001-2004)
Department of Microbiology and Immunology
Faculty of Medicine
Dalhousie University


“Fortune favours
the prepared mind.”
-Louis Pasteur-

Welcome to the Brassinga Lab


Our laboratory research is focused on studying Legionella pneumophila, the causative agent of Legionnaires’ Disease.


It is proposed that cyst-like forms, either free-form or within amoebae vesicles, when aerosolized in water droplets and inadvertently inhaled by susceptible individuals, infect alveolar macrophages, ultimately manifesting as an atypical pneumonia termed legionellosis or Legionnaires’ disease.


Individuals at high risk of contracting the disease are very often immunocompromised such as the elderly or transplant/cancer patients, whereas healthy individuals are at low risk.


We are interested in uncovering the molecular mechanisms that control the differentiation of replicating bacteria into cyst-like forms by studying the global regulatory cascade that controls the developmental cell-cycle program.


Studying L. pneumophila in the C. elegans host model presents another approach in the investigation as to how L. pneumophila successfully infects human macrophages.

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